Assessment Of Mineral-Bone Diseases & Osteoporosis Among Hemodialysis Patients In Aswan

Abstract

Objective

Chronic kidney disease is linked to presence of mineral bone disorder (MBD), fragility fractures and osteoporosis. It results from reduced bone mineral density as well as abnormalities in bone turnover. This study aimed to assess MBD and osteoporosis among hemodialysis patients.

Methods

This study adopted a cross-sectional design. It was performed in Aswan-Egypt; from December 2022 until December 2023. The study comprised 100 patients on hemodialysis. All patients underwent general examinations and a full medical history. Investigations included complete blood count, urea, creatinine, parathyroid hormone (PTH), calcium, phosphorus, vitamin D level (vit D) , Dual-energy x-ray absorptiometry and Fracture risk score (FRAX)

Results

Mean± SD of patients’ age was 49.4 ± 13.32 years. There were 36 males and 64 females, 45 of them were menopause. The incidence of osteoporosis was 66%, while the incidence of osteopenia was 72% among our patients. 19 patients had moderate fracture risk, while 6 patients had high fracture risk. Our study revealed that 18 patients had low PTH and 71 had high PTH. Also, 65 patients suffered from vit D deficiency and 14 suffered from vit D insufficiency. Finally, FRAX was significantly increased in females than males (P

=0.002), in menopause females than non-menopause females (P <0.001), in osteoporotic patients than non- osteoporotic patients (P<0.001) and in subjects with vit D deficiency than those without vit D deficiency (P =0.039).

Conclusion

The study identified a significant prevalence of vit D deficiency, osteoporosis and osteopenia among our hemodialysis patients.