The Effect Of Different Concentrations Of Ammi Visnaga Plant On Biochemical Changes In Hyperglycemic Rats

Abstract

Ammi visnaga is a plant known for improving blood sugar by containing many bioactive compounds, also containing essential oils that are strong vasodilators, with its extracts being used in pharmaceutical products. Aim: establish the research aims regarding the effects of differing concentrations of Ammi visnaga on biochemical changes in hyperglycemic mice. Materials and Methods: Thirty-six male Sprague Dawley rats were divided into normal (n=6) and diabetic (n=30). The second group was injected with streptozotocin (at a dose of 75 mg/ kg intraperitoneally), and those with blood glucose concentrations more than 250 mg/dL were classified as diabetic. Rats were divided into six groups, (1) non-diabetic group (n=6) received distilled water (2 mL/ day); (2) diabetic control group (n=6) received distilled water (2 mL/ day); (3) diabetic group (n=6) received basal diet +5% Ammi visnaga; (4) diabetic group (n=6) received basal diet +10% Ammi visnaga; (5) diabetic group (n=6) received basal diet +15% Ammi visnaga.(6)  diabetic group (n=6) received a basal diet +20% Ammi visnaga. After 28 days, blood was collected, and serum was extracted to determine glucose, liver enzymes, kidney function, and blood lipids  Results: At the end of the experiment, the glucose level was significantly reduced (p<0.05). The values of all groups were significantly lower in liver enzymes and lipid profile as compared to the control positive. Conclusion: The results of the present study showed that  Ammi visnaga has the therapeutic potential to control the progression of complete episodes of diabetes by controlling the pre-diabetic status..