Nutritional Nanoparticles As Neuroprotection Vehicles: Integration Of Bioactive Nutrients In The Therapy Of Neurodegenerative Diseases

Abstract

Neurodegenerative diseases represent a major therapeutic challenge due to the blood-brain barrier and low brain bioavailability of many compounds with therapeutic potential. In recent years, strategies based on nutritional nanoparticles (NPs)—that is, NPs that carry bioactive nutrients or nutraceuticals—have emerged to circumvent these barriers and provide neuroprotective effects. This article reviews recent advances (2020-2025) in the design of nanoparticles to deliver compounds such as curcumin, resveratrol, quercetin, and omega-3 fatty acids to the central nervous system, discussing delivery platforms, blood-brain barrier crossing mechanisms, preclinical outcomes, safety challenges, and future prospects. It is concluded that these formulations have great potential, but require systematic toxicity studies, brain biodistribution and well-designed clinical trials.